May 10, 2026

Constipation Drug for Kidney Disease: Scientists Found A New Weapon

Constipation Drug for Kidney Disease: Scientists Found A New Weapon

Millions of people have a misconception that constipation affects the stomach primarily.

This is why you will find people telling you to drink plenty of water to prevent constipation and keep your kidneys healthy.

Constipation is extremely common. But kidney disease is more concerning.
You might have heard a lot about kidney patients' digestive problems. Here is a study combining the two: Constipation Treatment for Kidney Disease. So this study is going to be interesting for both segments (constipation and kidney problems).

Why Constipation Is Really Bad For Your Kidney

Today, you will find millions of people suffering from chronic kidney disease and taking renal disease treatment.

There are experienced nephrologists in Kolkata. Even if you or any of your acquaintances is suffering from kidney problems, they must be under the watchful eyes of doctors doing Nephrology treatment in Birati.

However, in the context of constipation, you must understand why it impacts your kidneys.

Constipation can indeed impact the gut-kidney axis, which is the link between digestive function and kidney health.

Just ask your nearest Nephrologist in North Dumdum, they may tell you the following:

• If you are unable to go to the washroom, the substances stay in your intestines for a longer period. This is not good at all.

• Moreover, the amount of inflammation goes up.

• n addition, these poisons may seep into the blood, causing your kidneys to work hard to filter them out.

This is how Gut health and kidneys are interrelated, and hence, you have to be careful.

Latest Revelation: Constipation For Kidney Disease

Scientists and researchers at Tohoku University, Japan, made a pathbreaking revelation concerning the constipation drug, Lubiprostone.

This drug may slow down the process of kidney failure in CKD patients. This innovative kidney treatment is indeed bringing in an air of positivity in nephrology.

In a phase 2 trial involving 150 participants suffering from moderate levels of CKD, they were given 8 to 16 micrograms of Lubiprostone for 24 weeks.

Key Observations of the Research

It was found that those who received the Lubiprostone experienced a slower decline in Glomerular filtration rates compared to those who were given a placebo.

Most importantly, the researchers observed that the function of the kidneys miraculously improved in this set of people. Their gut-derived toxin levels did not undergo any significant change.

Earlier studies hinted at improving gut health for the protection of the kidneys. Due to inadequate research, the phase 2 study involving the new constipation drug was conducted.

Moreover, in relation to the Kidney disease constipation treatment, it was found that Lubiprostone increased the production of spermidine.

Now what is it? Spermidine is a compound that naturally occurs in the human body. 

Moving on with the research, the production of spermidine resulted in increased mitochondrial activity (Mitochondria are known to generate energy cells).

Who knows, in the days to come, this treatment will be provided in your locality, Kidney Care Hospital, North Dumdum.

FAQs

Q1. I have chronic constipation. Can it worsen my kidneys?

Yes, if you have constipation, it may severely increase the buildup of toxins in your body. This development can indirectly increase pressure on your kidney function.

Q2. If an individual is a kidney patient, can they take laxatives on a regular basis?

No, they need to be watchful. Not all laxatives are safe. Hence, it is safe to consult a Kidney specialist near Birati.

Q3. Which foods help relieve constipation?

Kidney-friendly fibre sources, vegetables, and controlled liquid intake help in managing constipation.

Q4. What are the FDA-approved constipation medicines?

The FDA-approved medicines for constipation include Trulance (plecanatide), Amitiza (Lubiprostone), Linzess (linaclotide), Motegrity (Prucalopride), etc.

Q5. Can I find CKD treatment in North Dumdum?

Yes, you can find nephrologists offering chronic kidney treatments in the North Dumdum area.